5-Methoxycanthinone (Synonyms: 5-Methoxycanthin-6-one, NSC 88929) |
Catalog No.GC46705 |
La 5-metoxicantinona es un inhibidor activo por vÍa oral de las cepas de Leishmania.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 15071-56-4
Sample solution is provided at 25 µL, 10mM.
5-Methoxycanthinone is an alkaloid that has been found in L. floridana and has anticancer properties.1 It is cytotoxic to KB, A549, and HCT-8 cells (EC50s = 2.9, 3.1, and 2.5 µg/ml, respectively). It is active against the P. falciparum mefloquine-resistant strain F32 and the multidrug and chloroquine-resistant strain K1 (IC50s = 10.4 and 5.1 µg/ml, respectively).2 However, it increases the parasite load by 68.4% in a mouse model of leishmaniasis when administered at a dose of 10 mg/kg per day.3
1.Xu, Z., Chang, F.R., Wang, H.-K., et al.Anti-HIV agents 45 and antitumor agents 205. Two new sesquiterpenes, leitneridanins A and B, and the cytotoxic and anti-HIV principles from Leitneria floridanaJ. Nat. Prod.63(12)1712-1715(2000) 2.CebriÁn-TorrejÓn, G., Spelman, K., Leblanc, K., et al.The antiplasmodium effects of a traditional South American remedy: Zanthoxylum chiloperone var. Angustifolium against chloroquine resistant and chloroquine sensitive strains of Plasmodium falciparumRevista Brasileira de Farmacognosia21(4)652-661(2011) 3.Ferreira, M.E., Rojas de Arias, A., Torres de Ortiz, S., et al.Leishmanicidal activity of two canthin-6-one alkaloids, two major constituents of Zanthoxylum chiloperone var. angustifoliumJ. Ethnopharmacol.80(2-3)199-202(2002)
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