L-Serine-13C3 (Synonyms: (S)-Serine-13C3) |
| Catalog No.GC49417 |
L-Serine-13C3 ((-)-Serine-13C3) es la L-Serina marcada con 13C. L-Serine ((-)-Serine; (S)-Serine), uno de los llamados aminoÁcidos no esenciales, juega un papel central en la proliferaciÓn celular.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 201595-68-8
Sample solution is provided at 25 µL, 10mM.
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L-Serine-13C3 is intended for use as an internal standard for the quantification of L-serine by GC- or LC-MS. L-Serine is a non-essential amino acid.1 It is produced from 3-phosphoglycerate in a multistep biosynthesis catalyzed by phosphoglycerate dehydrogenase (PGDH), phosphoserine aminotransferase (PSAT), and phosphoserine phosphatase (PSP). L-Serine can also be derived from dietary sources, as well as protein and phospholipid turnover. Defective L-serine biosynthesis is associated with neural tube defects and deoxysphingolipid accumulation in patients with Neu-Laxova syndrome, a rare disease characterized by a mutation in PGDH.1,2 Dysregulation of L-serine phosphorylation is associated with disease progression in patients with neurodegenerative diseases, including Alzheimer’s disease and amyotrophic lateral sclerosis.
1.Holm, L.J., and Buschard, K.L-serine: A neglected amino acid with a potential therapeutic role in diabetesAPMIS127(10)655-659(2019) 2.Metcalf, J.S., Dunlop, R.A., Powell, J.T., et al.L-serine: A naturally-occurring amino acid with therapeutic potentialNeurotox. Res.33(1)213-221(2018)
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