ML604086 |
| Catalog No.GC39649 |
ML604086 es un inhibidor selectivo de CCR8 que inhibe la uniÓn de CCL1 a CCR8 en las células T circulantes.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 850330-18-6
Sample solution is provided at 25 µL, 10mM.
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ML604086 is a selective CCR8 inhibitor, inhibiting CCL1 binding to CCR8 on circulating T-cells. ML604086 inhibits CCL1 mediated chemotaxis and increases in intracellular Ca2+ concentrations[1][2].
[1]. James E. Pease, et al. Chemokine Receptors in Allergy, Inflammation, and Infectious Disease. Top Med Chem (2015) 14: 1-40. [2]. Lin Wang, et al. Antagonism of chemokine receptor CCR8 is ineffective in a primate model of asthma. Thorax 2013;68:506-512.
Average Rating: 5 (Based on Reviews and 10 reference(s) in Google Scholar.)
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