MMG-0358 |
Catalog No.GC47694 |
An inhibitor of IDO1
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1378976-02-3
Sample solution is provided at 25 µL, 10mM.
MMG-0358 is an inhibitor of indolamine 2,3-dioxygenase 1 (IDO1; IC50s = 2 and 80 nM for the mouse and human enzyme, respectively).1,2 It is selective for IDO1 over tryptophan 2,3-dioxygenase (TDO; IC50s = >100 µM for mouse and human TDO).1
1.RÖhrig, U.F., Majjigapu, S.R., Grosdidier, A., et al.Rational design of 4-aryl-1,2,3-triazoles for indoleamine 2,3-dioxygenase 1 inhibitionJ. Med. Chem.55(11)5270-5290(2012) 2.RÖhrig, U.F., Reynaud, A., Majjigapu, S.R., et al.Inhibition mechanisms of indoleamine 2,3-dioxygenase 1 (IDO1)J. Med. Chem.62(19)8784-8795(2019)
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