Onychocin B

Name: Onychocin B
Brand: GlpBio
SKU: GC48438
Availability: InStock
Rating: 5 (35 reviews)

Catalog No.GC48438

A cyclic tetrapeptide with calcium channel inhibitory activity

Products are for research use only. Not for human use. We do not sell to patients.

Onychocin B Chemical Structure

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250µg	237,00 $	Disponible
1mg	852,00 $	Disponible

Tel：(909) 407-4943 Email: sales@glpbio.com

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Based on customer reviews.

Sample solution is provided at 25 µL, 10mM.

GlpBio Products Cited In Reputable Papers

Nature
610.7931 (2022): 366-372

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618, 1017–1023 (2023)

Cell
183.7 (2020): 1867-1883

Cell Research
31, 1291–1307 (2021)

Cell Research
33, 273–287 (2023)

Cell Research
33, 546–561 (2023)

Molecular Cancer
21.1 (2022): 1-17

Molecular Cancer
21.1 (2022): 1-18

Cancer Cell
39 (2021): 1-16

Cell Host Microbe
30.8 (2022): 1124-1138

Cell Host Microbe
31.5 (2023): 766-780

Cell Host Microbe
31.3 (2023): 418-43

Cell Metabolism
34.2 (2022): 240-255

Ann Rheum Dis
82(4): 533-545 (2023)

Cell Mol Immunol
20, 264–276 (2023)

Adv Funct Mater
33.35 (2023): 2214998

Description Chemical Properties Product Documents

Product Documents

Quality Control & SDS

View current batch:

Purity: >95.00%

Onychocin B is a cyclic tetrapeptide originally isolated from Onychocola sclerotica that has calcium channel inhibitory activity.¹ It inhibits the voltage-gated calcium (Ca_v) channel Ca_v1.2 with an IC₅₀ value of 7.1 µM.

1.PÉrez-Victoria, I., MartÍn, J., GonzÁlez-MenÉndez, V., et al.Isolation and structural elucidation of cyclic tetrapeptides from Onychocola scleroticaJ. Nat. Prod.75(6)1210-1214(2012)

Cas No.		SDF
Canonical SMILES	O=C([C@H](C(C)C)NC([C@@H](CC1=CC=CC=C1)N(C)C2=O)=O)N([C@@H](CC3=CC=CC=C3)C(N[C@@]2([H])[C@@H](C)CC)=O)C
Formula	C31H42N4O4	M.Wt	534.7
Solubility		Storage	-20°C
General tips	Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition	Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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		1 mg	5 mg	10 mg
	1 mM	1.8702 mL	9.351 mL	18.7021 mL
	5 mM	0.374 mL	1.8702 mL	3.7404 mL
	10 mM	0.187 mL	0.9351 mL	1.8702 mL

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 35 reference(s) in Google Scholar.)

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Onychocin B

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