HSGN-218 |
| Catalog No.GC48523 |
A gut-restrictive antibiotic
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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HSGN-218 is a gut-restrictive antibiotic.1 It is active against C. difficile (MIC = 0.007 µg/ml) and clinical isolates of C. difficile (MICs = 0.003-0.03 µg/ml) and is not cytotoxic to Caco-2 cells when used at concentrations ranging from 4 to 64 µg/ml. HSGN-218 (50 mg/kg) increases survival and protects mice from C. difficile recurrence in mouse models of C. difficile infection.
1.Naclerio, G.A., Abutaleb, N.S., Li, D., et al.Ultrapotent inhibitor of Clostridioides difficile growth, which suppresses recurrence in vivoJ. Med. Chem.63(20)11934-11944(2020)
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