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ML-SI1 (Synonyms: DMSO : 100 mg/mL (222.53 mM; Need ultrasonic))

Catalog No.GC19764

ML-SI1, una mezcla racémica de diastereómeros, es un inhibidor de TRPML con un valor IC50 de 15 μM para TRPML1.

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ML-SI1 Chemical Structure

Tamaño Precio Disponibilidad Cantidad
5mg
333,00 $
Disponible
10mg
551,00 $
Disponible
25mg
1.045,00 $
Disponible
50mg
1.615,00 $
Disponible
100mg
2.375,00 $
Disponible

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

ML-SI1, a racemic mixture of diastereomers, is a TRPML inhibitor with an IC50 value of 15 μM for TRPML1.

ML-SI1 is an inseparable racemic mixture of cis-/trans-isomers (55:45) in a short synthetic sequence and its inhibitory activity on hTRPML1 (and a weak effect on TRPML2) after activation with ML-SA1. Fura-2 based single cell calcium imaging experiments confirmed that the synthesized racemic ML-SI1 (10 μM) has an inhibitory effect on hTRPML1[1].

Reference:
[1]. Charlotte Leser, et al. Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3. Eur J Med Chem. 2021 Jan 15;210:112966.

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