LCS3 |
| Catalog No.GC49753 |
LCS3 es un inhibidor reversible y no competitivo de la glutatiÓn disulfuro reductasa (GSR) y la tiorredoxina reductasa 1 (TXNRD1) (IC50=3,3 μM y 3,8 μM, respectivamente). LCS3 muestra actividad antitumoral e induce la apoptosis. LCS3 se puede utilizar en la investigaciÓn del adenocarcinoma de pulmÓn (LUAD).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 109844-92-0
Sample solution is provided at 25 µL, 10mM.
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LCS3 is an inhibitor of glutathione reductase (GR) and thioredoxin reductase (TrxR; IC50s = 3.3 and 3.8 µM, respectively).1 It decreases the glutathione (GSH) to oxidized GSH (GSSG) ratio in NCI H1650 and H23 lung adenocarcinoma cells in a concentration-dependent manner. LCS3 (3 µM) induces apoptosis in NCI H1650 and H23 cells but not non-transformed HPL1D lung epithelial cells. It is also active against M. tuberculosis (MIC = 0.098 µM).2
1.Johnson, F.D., Ferrarone, J., Liu, A., et al.Characterization of a small molecule inhibitor of disulfide reductases that induces oxidative stress and lethality in lung cancer cellsCell Rep.38(6)110343(2022) 2.Gallardo-Marcias, R., Kumar, P., Jaskowski, M., et al.Optimization of N-benzyl-5-nitrofuran-2-carboxamide as an antitubercular agentBioorg. Med. Chem. Lett.29(4)601-606(2019)
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