Desmethyl Sibutramine (hydrochloride) (Synonyms: BTS-54354) |
| Catalog No.GC49870 |
An active metabolite of sibutramine
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Cas No.: 84467-94-7
Sample solution is provided at 25 µL, 10mM.
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Desmethyl sibutramine is an active metabolite of sibutramine.1 It prevents reserpine-induced ptosis in rats (ED50 = 4.2 mg/kg) and decreases immobility in the Porsolt learned helplessness test in mice when administered at a dose of 10 mg/kg.
1.Luscombe, G.P., Hopcroft, R.H., Tomas, P.C., et al.The contribution of metabolites to the rapid and potent down-regulation of rat cortical β-adrenoceptors by the putative antidepressant sibutramine hydrochlorideNeuropharmacology28(2)129-134(1989)
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