Herniarin (7-Methoxycoumarin) (Synonyms: Ayapanin, Gerniarin, Herniarin, Methylumbelliferone, NSC 404559) |
| Catalog No.GC34148 |
La herniarina (7-Metoxicumarina) es una cumarina natural que se encuentra en algunas plantas con flores, con efecto antitumoral.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 531-59-9
Sample solution is provided at 25 µL, 10mM.
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Herniarin is a natural coumarin occurs in some flowering plants, with antitumor effect.
Herniarin is cytotoxic to breast carcinoma cell line MCF-7 with an IC50 of 207.6 µM. Herniarin (100 µM) also induces apoptosis in MCF-7 cells[1]. Herniarin alone has no obvious cytotoxicity on transitional cell carcinoma (TCC) cells, but when in combination with 5 µg/mL cisplatin, Herniarin (80 µg/mL) potently enhances the antitumor effect of cisplatin, and increases chromatin condensation[2].
[1]. Mousavi SH, et al. Comparative analysis of the cytotoxic effect of 7-prenyloxycoumarin compounds and herniarin on MCF-7 cell line. Avicenna J Phytomed. 2015 Nov-Dec;5(6):520-30. [2]. Haghighitalab A, et al. Enhancement of cisplatin cytotoxicity in combination with herniarin in vitro. Drug Chem Toxicol. 2014 Apr;37(2):156-62.
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