CaV1.3 antagonist-1 |
| Catalog No.GC65959 |
El antagonista 1 de CaV1.3 es un antagonista de los canales de calcio tipo L (LTCC) de CaV1.3 potente y altamente selectivo con una IC50 de 1,7 μM. CaV1.3 antagonista-1 inhibe CaV1.3 LTCC > 600 veces mÁs potente que CaV1.2 LTCC. CaV1.3 antagonista-1, un derivado de ciclopentilo, tiene potencial para la investigaciÓn de la enfermedad de Parkinson'.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1391385-57-1
Sample solution is provided at 25 µL, 10mM.
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CaV1.3 antagonist-1 is a potent and highly selective CaV1.3 L-type calcium channel (LTCC) antagonist with an IC50 of 1.7 μM. CaV1.3 antagonist-1 inhibits CaV1.3 LTCC >600-fold more potently than CaV1.2 LTCC. CaV1.3 antagonist-1, a cyclopentyl derivative, has the potential for Parkinson's disease research[1].
CaV1.3 antagonist-1 (Compound 8; 5 μM) exhibits 31.2% and 4.4% inhibition for CaV1.3 and CaV1.2 channel current in HEK293 cells, respectively. This correlates with the results of the FLIPR assay[1].
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