CAY10614 |
| Catalog No.GC18883 |
CAY10614 es un potente antagonista de TLR4.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1202208-36-3
Sample solution is provided at 25 µL, 10mM.
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Lipid A is a lipid-rich component of endotoxin, also known as lipopolysaccharide (LPS), which in turn is part of the outer membrane of Gram-negative bacteria. Lipid A activates toll-like receptor 4 (TLR4), initiating an immune response. CAY10614 is an antagonist of lipid A activation of TLR4, exhibiting an IC50 value of 1.68 μM in a cell-based assay using modified human embryonic kidney (HEK) cells. It does not significantly affect HEK cell viability. In a model of sepsis, CAY10614 dramatically and significantly improves survival of mice given intraperitoneal LPS.
Review for CAY10614
Average Rating: 5 (Based on Reviews and 17 reference(s) in Google Scholar.)
Review for CAY10614
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