CCR2 antagonist 1 |
| Catalog No.GC30560 |
El antagonista CCR2 1 es un antagonista de alta afinidad y larga duración en el tiempo para CCR2, con una Ki de 2.4 nM.
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Cas No.: 1683534-96-4
Sample solution is provided at 25 µL, 10mM.
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CCR2 antagonist 1 is a high-affinity and long-residence-time CCR2 antagonist, with a Ki of 2.4 nM.
The combination of SAR and SKR in the hit-to-lead process results in the discovery of a new higheaffinity and longeresidenceetime CCR2 antagonist (CCR2 antagonist 1 (compound 15a), Ki=2.4 nM; RT=714 min)[1].
[1]. Vilums M, et al. When structure-affinity relationships meet structure-kinetics relationships: 3-((Inden-1-yl)amino)-1-isopropyl-cyclopentane-1-carboxamides as CCR2 antagonists. Eur J Med Chem. 2015 Mar 26;93:121-34.
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