Charybdotoxin (trifluoroacetate salt) (Synonyms: ChTX) |
| Catalog No.GC43235 |
Charybdotoxin is a peptide originally isolated from the scorpion L.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Charybdotoxin is a peptide originally isolated from the scorpion L. quinquestriatus that acts as a potassium channel blocker., It blocks large-conductance Ca2+-activated K+ channels (BKCas) in GH3 rat pituitary tumor cells and primary bovine aortic smooth muscle cells (Kds = 2.1 and ~2.1 nM, respectively). Charybdotoxin selectively blocks voltage-gated potassium (Kv) channels Kv1.2 and Kv1.3 over Kv1.1, Kv1.5, and Kv3.1 (Kds = 14, 2.6, >1,000, >100, >1,000 nM, respectively). It also blocks human large-conductance pH-activated potassium channel KCa5.1 (Slo3) by 47% at a concentration of 100 nM and pH of 7.4, and human intermediate-conductance Ca2+-activated K+ channel IKCa1/KCa3.1 (Kd = 10 nM).,
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