CXCR2-IN-1 |
| Catalog No.GC31754 |
CXCR2-IN-1 es un antagonista de CXCR2 que penetra en el sistema nervioso central con una pIC50 de 9,3.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1873376-49-8
Sample solution is provided at 25 µL, 10mM.
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CXCR2-IN-1 is a central nervous system penetrant CXCR2 antagonists with a pIC50 of 9.3.
CXCR2 plays an important role in the activation and recruitment of neutrophils to sites of inflammation. CXCR2-IN-1 shows favorable central nervous system penetration property (Br/Bl>0.45)[1].
CXCR2-IN-1 shows efficacy in a cuprizone-induced demyelination model through oral administration, providing evidence to support CXCR2 to be a potential therapeutic target to treat demyelinating diseases such as multiple sclerosis[1].
[1]. Xu H, et al. Discovery of CNS Penetrant CXCR2 Antagonists for the Potential Treatment of CNS Demyelinating Disorders. ACS Med Chem Lett. 2016 Feb 8;7(4):397-402.
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