Dehydronitrosonisoldipine |
Catalog No.GC33486
One-Click Copy Product Info
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La dehidronitrosonisoldipina, un derivado de la nisoldipina, es un inhibidor irreversible y permeable a las células estéril alfa y TIR que contiene el motivo 1 (SARM1).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 87375-91-5
Sample solution is provided at 25 µL, 10mM.
Dehydronitrosonisoldipine is a derivative of nisoldipine, which retains calcium channel antagonist activity while also possessing the ability to inhibit sterile alpha and TIR motif-containing protein 1 (SARM1), thus making it a dual-bioactive compound[1]. Dehydronitrosonisoldipine irreversibly inhibits SARM1 activation by covalently modifying cysteine 311 of the SARM1 protein, thereby blocking downstream axonal degeneration (AxD) signaling pathways[2]. Dehydronitrosonisoldipine can be used to study the mechanisms of axonal degeneration associated with neurodegenerative diseases, such as exploring its role in chemotherapy-induced neuropathy (e.g., vincristine-induced neuropathy)[2].
References:
[1] Li W H, Huang K, Cai Y, et al. Permeant fluorescent probes visualize the activation of SARM1 and uncover an anti-neurodegenerative drug candidate[J]. Elife, 2021, 10: e67381.
[2] Feldman H C, Merlini E, Guijas C, et al. Selective inhibitors of SARM1 targeting an allosteric cysteine in the autoregulatory ARM domain[J]. Proceedings of the National Academy of Sciences, 2022, 119(35): e2208457119.
| Cas No. | 87375-91-5 | SDF | |
| Canonical SMILES | O=C(C1=C(C2=CC=CC=C2N=O)C(C(OCC(C)C)=O)=C(C)N=C1C)OC | ||
| Formula | C20H22N2O5 | M.Wt | 370.4 |
| Solubility | DMSO : 100 mg/mL (269.98 mM) | Storage | Store at -20°C, protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.6998 mL | 13.4989 mL | 26.9978 mL |
| 5 mM | 540 μL | 2.6998 mL | 5.3996 mL |
| 10 mM | 270 μL | 1.3499 mL | 2.6998 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.50% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 23 reference(s) in Google Scholar.)