diABZI-C2-NH2 |
| Catalog No.GC63473 |
diABZI-C2-NH2, un anÁlogo activo que contiene una funcionalidad de amina primaria, es un agonista de STING.
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Cas No.: 2137975-93-8
Sample solution is provided at 25 µL, 10mM.
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diABZI-C2-NH2, an active analogue containing a primary amine functionality, is a STING agonist[1].
The author developed a linking strategy to synergize the effect of two symmetry-related amidobenzimidazole (ABZI)-based compounds to create linked ABZIs (diABZIs) with enhanced binding to STING and cellular function. Intravenous administration of a diABZI STING agonist to immunocompetent mice with established syngeneic colon tumours elicited strong anti-tumour activity, with complete and lasting regression of tumors[1]. diABZI-C2-NH2 is covalently immobilized on sepharose beads and is used to affinity-capture potential target proteins from a THP1 cell lysate[1].
[1]. Ramanjulu JM, et al. Design of amidobenzimidazole STING receptor agonists with systemic activity [published correction appears in Nature. 2019 Jun;570(7761):E53]. Nature. 2018;564(7736):439-443.
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