DNase II |
Catalog No.GB10043
One-Click Copy Product Info
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DNase II is a lysosomal acid endonuclease.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 9025-64-3
Sample solution is provided at 25 µL, 10mM.
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DNase II is a lysosomal acid endonuclease. DNase II degrades DNA from apoptotic cells and DNA expelled from erythroblast nuclei under acidic conditions to clear self-nucleic acids. DNase II reduces autoinflammation by inhibiting the cGAS-STING/type I interferon pathway. DNase II can be used in studies of dyserythropoiesis, autoinflammatory syndrome, rheumatoid arthritis and systemic lupus erythematosus[1-4].
References:
[1] Evans CJ, Aguilera RJ. DNase II: genes, enzymes and function. Gene. 2003 Dec 11;322:1-15.
[2] Zhuang J, Du X, Liu K, et al. DNase II Can Efficiently Digest RNA and Needs to Be Redefined as a Nuclease. Cells. 2024 Sep 11;13(18):1525.
[3] Seong CS, Varela-Ramirez A, Aguilera RJ. DNase II deficiency impairs innate immune function in Drosophila. Cell Immunol. 2006 Mar;240(1):5-13.
[4] Shiokawa D, Tanuma S. DLAD, a novel mammalian divalent cation-independent endonuclease with homology to DNase II. Nucleic Acids Res. 1999 Oct 15;27(20):4083-9.
| Cas No. | 9025-64-3 | SDF | Download SDF |
| Formula | M.Wt | ||
| Solubility | Storage | -20℃ | |
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Biological Activity: 855 u/mg solid Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)