EPI-X4 (trifluoroacetate salt) (Synonyms: Endogenous Peptide Inhibitor of CXCR4) |
| Catalog No.GC91465 |
EPI-X4 es un fragmento de péptido endógeno que corresponde a los aminoácidos 408-423 de la albúmina sérica humana y es un antagonista del receptor 4 de quimiocina (motivo C-X-C) (CXCR4).
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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EPI-X4 is an endogenous peptide fragment corresponding to amino acids 408-423 of human serum albumin and an antagonist of chemokine (C-X-C motif) receptor 4 (CXCR4).1 It inhibits calcium mobilization and receptor internalization induced by chemokine (C-X-C motif) ligand 12 (CXCL12) in HEK293 cells expressing CXCR4 when used at concentrations ranging from 0.8 to 1,000 µM. EPI-X4 inhibits CXCL12-induced migration of Jurkat T cells and human CD34+ hematopoietic stem cells. In vivo, EPI-X4 (16 µmol/kg) reduces Cxcr4-dependent inflammatory cell airway infiltration in a mouse model of acute allergic airway hypereosinophilia. Urinary levels of EPI-X4 are increased and inversely correlated with glomerular filtration rate (GFR) in patients with chronic kidney disease.
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