Fosnetupitant |
| Catalog No.GC64711 |
Fosnetupitant (Pronetupitant) un profÁrmaco de fosfato de metileno de Netupitant.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1703748-89-3
Sample solution is provided at 25 µL, 10mM.
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Fosnetupitant (Pronetupitant) a methylene phosphate prodrug of Netupitant. Fosnetupitant (Pronetupitant) exhibits a pKi of 9.5 for human NK1 receptor[1].
Fosnetupitant (Pronetupitant) displays micromolar affinity for the 5-HT6 (pKi ∼ 5.2) receptor and type L Ca2+ channels (pKi ∼ 5.7) and does not bind all the other proteins investigated[1].
Pronetupitant is rapidly and extensively converted to Netupitant after i.v. injection in rats[1].
[1]. Ruzza C, et al. In vitro and in vivo pharmacological characterization of Pronetupitant, a prodrug of the neurokinin 1 receptor antagonist Netupitant. Peptides. 2015 Jul;69:26-32.
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