Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH₂ |
| Catalog No.GA23179 |
The N-terminal elongation of the widely used MMP FRET substrate Mca-PLGL-Dpa-AR-NH? (M-1895) with a Lys yields a fluorogenic peptide with improved substrate properties. As compared to M-1895, the specificity constant (kcat/Km) of the broad-spectrum MMP-substrate M-2350, Mca-KPLGL-Dpa-AR-NH? for collagenases (MMP-1, MMP-8, MMP-13) and MMP-14 is increased two- to ninefold and threefold, respectively, while those for gelatinases and matrilysin remain equally high.
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Cas No.: 720710-69-0
Sample solution is provided at 25 µL, 10mM.
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The N-terminal elongation of the widely used MMP FRET substrate Mca-PLGL-Dpa-AR-NH with a Lys yields a fluorogenic peptide with improved substrate properties. As compared to Mca-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2, the specificity constant (kcat/Km) o
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