PACAP-38 (human, mouse, ovine, porcine, rat) |
| Catalog No.GA23341 |
Kojro et al. observed that the PAC1 agonists PACAP-27 (H-1172) and PACAP-38 strongly increased the activity of α-secretase. Upregulation of this APP-degrading enzyme promotes the non-amyloidogenic processing of APP, i.e. reduces the production of Aβ40/42, and thus may help to prevent Alzheimer's disease. Nasally applied PACAP-38 in APP[V717I]-transgenic mice additionally enhanced the production of the Aβ-degrading enzyme neprilysin via induction of somatostatin.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 124123-15-5
Sample solution is provided at 25 µL, 10mM.
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Kojro et al. observed that the PAC1 agonists PACAP-27 and PACAP-38 strongly increased the activity of α-secretase. Upregulation of this APP-degrading enzyme promotes the non-amyloidogenic processing of APP, i.e. reduces the production of Aβ40
Average Rating: 5 (Based on Reviews and 37 reference(s) in Google Scholar.)
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