SNT-207858 free base |
| Catalog No.GC38107 |
La base libre SNT207858 es un antagonista del receptor de melanocortina-4 (MC-4) selectivo, penetrante de la barrera hematoencefÁlica, potente y activo por vÍa oral.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1104662-66-9
Sample solution is provided at 25 µL, 10mM.
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SNT207858 free base is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist. SNT207858 free base has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor[1].
SNT207858 binds to the MC-4 receptor with an affinity of 22 nM and shows a 170-fold selectivity vs. MC-3 and a 40-fold selectivity vs. MC-5[1].
SNT207858 (30 mg/kg; oral administration; once daily; 15 days) significantly reduces the tumor induced weight loss in mice[1]. Animal Model: Mice with C26 adenocarcinoma-induced cachexia model[1]
[1]. Weyermann P, et al. Orally available selective melanocortin-4 receptor antagonists stimulate food intake and reduce cancer-induced cachexia in mice. PLoS One. 2009;4(3):e4774.
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
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