Pimonidazole hydrochloride |
| Catalog No.GC38652 |
El pimonidazol es un nuevo marcador de hipoxia para el estudio complementario de la hipoxia tumoral y la proliferaciÓn celular en el tumor. El pimonidazol se acumula en las células hipÓxicas a través de la uniÓn covalente con macromoléculas o mediante la formaciÓn de metabolitos reductores después de la reducciÓn de su grupo nitro, puede usarse para la evaluaciÓn cualitativa y cuantitativa de la hipoxia tumoral.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 70132-51-3
Sample solution is provided at 25 µL, 10mM.
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Pimonidazole is a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in tumor[1]. Pimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after reduction of its nitro group, it can be used for qualitative and quantitative assessment of tumor hypoxia [2].
[1]. Varia MA, et al. Pimonidazole: a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in cervical carcinoma. Gynecol Oncol. 1998 Nov;71(2):270-7. [2]. Masaki Y, et al. Imaging Mass Spectrometry Revealed the Accumulation Characteristics of the 2-Nitroimidazole-Based Agent "Pimonidazole" in Hypoxia. PLoS One. 2016 Aug 31;11(8):e0161639.
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