Giredestrant (Synonyms: GDC-9545) |
Catalog No.GC39630 |
Giredestrant (GDC-9545), un ligando no esteroideo del receptor de estrógeno (ER), es un antagonista selectivo y activo por vía oral del ER. Giredestrant compite potente con el Estradiol para la unión e induce un cambio conformacional dentro del dominio de unión al ligando del ER. Giredestrant tiene actividad antitumoral.
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Cas No.: 1953133-47-5
Sample solution is provided at 25 µL, 10mM.
Giredestrant (GDC-9545), a non-steroidal ER ligand, is an orally active and selective estrogen receptor (ER) antagonist. Giredestrant potently competes with estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor activity[1].
[1]. C Metcalfe, et al. Abstract P5-04-07: GDC-9545: A novel ER antagonist and clinical candidate that combines desirable mechanistic and pre-clinical DMPK attributes
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