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Giredestrant (Synonyms: GDC-9545)

Catalog No.GC39630

Giredestrant (GDC-9545), un ligando no esteroideo del receptor de estrógeno (ER), es un antagonista selectivo y activo por vía oral del ER. Giredestrant compite potente con el Estradiol para la unión e induce un cambio conformacional dentro del dominio de unión al ligando del ER. Giredestrant tiene actividad antitumoral.

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Giredestrant Chemical Structure

Cas No.: 1953133-47-5

Tamaño Precio Disponibilidad Cantidad
10mM (in 1mL DMSO)
294,00 $
Disponible
1mg
117,00 $
Disponible
5mg
256,00 $
Disponible
10mg
410,00 $
Disponible

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

Giredestrant (GDC-9545), a non-steroidal ER ligand, is an orally active and selective estrogen receptor (ER) antagonist. Giredestrant potently competes with estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor activity[1].

[1]. C Metcalfe, et al. Abstract P5-04-07: GDC-9545: A novel ER antagonist and clinical candidate that combines desirable mechanistic and pre-clinical DMPK attributes

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Average Rating: 5 ★★★★★ (Based on Reviews and 21 reference(s) in Google Scholar.)

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