Helenalin (Synonyms: NSC 85236) |
| Catalog No.GC43810 |
Helenalin es una lactona sesquiterpénica antiinflamatoria.
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Cas No.: 6754-13-8
Sample solution is provided at 25 µL, 10mM.
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Helenalin is a sesquiterpene lactone first isolated from various species of Arnica. It has anti-inflammatory effects, most notably by inhibiting gene expression mediated by NF-κB at doses from 1 to 20 µM. Like other sesquiterpene lactones, helenalin can modify sulfhydryl groups of cysteine residues and it alkylates these groups on the p65 subunit of NF-κB. It also suppresses the proliferation of cancer cells through multiple mechanisms, including the prevention of signaling through NF-κB. Helenalin has antibacterial and anti-protozoal activities.
Average Rating: 5 (Based on Reviews and 40 reference(s) in Google Scholar.)
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