IFN alpha-IFNAR-IN-1 hydrochloride |
| Catalog No.GC60927 |
El clorhidrato de IFN alfa-IFNAR-IN-1 es un inhibidor no peptÍdico de bajo peso molecular de la interacciÓn entre IFN-α e IFNAR; inhibir las respuestas de IFN-α inducidas por MVA por BM-pDC (IC50 = 2-8 uM).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2070014-98-9
Sample solution is provided at 25 µL, 10mM.
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IFN alpha-IFNAR-IN-1 hydrochloride is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR; inhibit MVA-induced IFN-α responses by BM-pDCs (IC50=2-8 uM).IC50 value:Target: IFN alpha-IFNAR interaction inhibitorIFN alpha-IFNAR-IN-1 specifically inhibits MVA-induced IFN-α responses by BM-pDCs. IFN alpha-IFNAR-IN-1 inhibited the IFN-α responses that were elicited after treatment with CpG2216, stimulation with poly(I:C), and infection with VSV-M2, whereas the total IL-12 production was notably less affected under those conditions. IFN alpha-IFNAR-IN-1 exerts immunosuppressive activity by the direct interaction with IFN-α [1].
[1]. Geppert T, et al. Immunosuppressive small molecule discovered by structure-based virtual screening for inhibitors of protein-protein interactions. Angew Chem Int Ed Engl. 2012 Jan 2;51(1):258-61.
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