Lenalidomide-C5-NH2 hydrochloride |
| Catalog No.GC60985 |
El clorhidrato de lenalidomida-C5-NH2 es el ligando de Cereblon basado en lenalidomida que se utiliza en el reclutamiento de la proteÍna CRBN. La lenalidomida-C5-NH2 se puede conectar al ligando de la proteÍna mediante un conector para formar PROTAC, como el degradador MDM2 PROTAC.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Lenalidomide-C5-NH2 hydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-NH2 can be connected to the ligand for protein by a linker to form PROTACs, such as MDM2 PROTAC degrader[1][2].
[1]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481. [2]. Yangbing Li, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression. J Med Chem. 2019 Jan 24;62(2):448-466.
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