MEN 10376 (Synonyms: DYWVWWK-NH2, Asp-Tyr-Trp-Val-Trp-Trp-Lys-NH2) |
Catalog No.GC17547
One-Click Copy Product Info
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Men 10376 es un antagonista selectivo del receptor NK-2 de taquiquinina, con una Ki de 4,4 μM para el receptor NK-2 de intestino delgado de rata.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 135306-85-3
Sample solution is provided at 25 µL, 10mM.
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Men 10376 is a selective tachykinin NK-2 receptor antagonist, with a Ki of 4.4 μM for rat small intestine NK-2 receptor.
Men 10376 is a selective tachykinin NK-2 receptor, with a Ki of 4.4 μM, and shows low selectivity for NK-1 and NK-3 receptors (Ki, >10 μM)[1]. Men 10376 shows pA2s of 5.66 and 8.08 for NK-1 (guinea-pig ileum) and NK-2 receptors (endothelium-deprived rabbit pulmonary artery). Men 10376 shows no effect on NK-3 receptor (Ki, >10 μM)[2].
Men 10376 (1 and 3 μmol/kg) antagonizes increase in bladder motility produced by the NK-2 receptor agonist in rats[2].
References:
[1]. Quartara L, et al. N-terminal truncated analogs of men 10376 as tachykinin NK-2 receptor antagonists. Life Sci. 1992;51(25):1929-36.
[2]. Maggi CA, et al. In vivo evidence for tachykininergic transmission using a new NK-2 receptor-selective antagonist, MEN 10,376. J Pharmacol Exp Ther. 1991 Jun;257(3):1172-8.
| Cas No. | 135306-85-3 | SDF | |
| Sinónimos | DYWVWWK-NH2, Asp-Tyr-Trp-Val-Trp-Trp-Lys-NH2 | ||
| Chemical Name | (3S,6S,9R,12R,15S,18S,21R)-9,15,18-tris((1H-indol-3-yl)methyl)-3,25-diamino-21-carbamoyl-6-(4-hydroxybenzyl)-12-isopropyl-4,7,10,13,16,19-hexaoxo-5,8,11,14,17,20-hexaazapentacosan-1-oic acid | ||
| Canonical SMILES | O=C([C@@H](C(C)C)NC([C@@H](CC1=CNC2=CC=CC=C12)NC([C@H](CC(C=C3)=CC=C3O)NC([C@H](CC(O)=O)N)=O)=O)=O)N[C@H](C(N[C@H](C(N[C@@H](C(N)=O)CCCCN)=O)CC4=CNC5=CC=CC=C45)=O)CC6=CNC7=CC=CC=C67 | ||
| Formula | C57H68N12O10 | M.Wt | 1081.24 |
| Solubility | Water : 1.43 mg/mL (1.20 mM) | Storage | Desiccate at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 924.9 μL | 4.6243 mL | 9.2486 mL |
| 5 mM | 185 μL | 924.9 μL | 1.8497 mL |
| 10 mM | 92.5 μL | 462.4 μL | 924.9 μL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)