ML-109 |
| Catalog No.GC31490 |
ML-109 es un agonista potente y completo del receptor de la hormona estimulante de la tiroides (TSHR), con un EC50 de 40 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1186649-91-1
Sample solution is provided at 25 µL, 10mM.
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ML-109 is a potent and full thyroid stimulating hormone receptor (TSHR) agonist, with an EC50 of 40 nM.
ML-109 (Compound 2) is a full agonist at TSHR with an EC50 of 40 nM and, like compound 1, it has no activity at FSHR or LHCGR. ML-109 contains an aminal, a functional group that is subject to hydrolysis and/or other degradation mechanisms. ML-109 is surprisingly stable at neutral and basic conditions (t1/2 of ~16 h) but is found to degrade at low pH (t1/2 of ~3 h)[1].
[1]. Neumann S, et al. Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice. Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12471-6.
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