MMV390048 |
| Catalog No.GC62109 |
MMV390048 es un representante de una nueva clase quÍmica de inhibidor de Plasmodium PI4K (Kdapp=0,3 μM).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1314883-11-8
Sample solution is provided at 25 µL, 10mM.
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MMV390048 is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kdapp=0.3 µM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. falciparum and human kinases apart from human PIP4K2C, thus alleviating potential kinase-mediated safety concerns. MMV390048 is an antimalarial agent[1].
MMV390048 against intraerythrocytic life cycle stages of P. falciparum (NF54 drug-sensitive strain) showed a steep inhibition curve with IC50 and IC90 values of 28 and 40 nM, respectively.
[1]. Paquet T, et al. Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase. Sci Transl Med. 2017 Apr 26;9(387). pii: eaad9735.
Average Rating: 5 (Based on Reviews and 40 reference(s) in Google Scholar.)
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