MT1 |
| Catalog No.GC61097 |
MT1 es una sonda quÍmica bivalente de bromodominios BET, con un IC50 de 0,789 nM para BRD4(1).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2060573-82-0
Sample solution is provided at 25 µL, 10mM.
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MT1 is a bivalent chemical probe of BET bromodomains, with an IC50 of 0.789 nM for BRD4(1)[1].
MT1 (100 nM, 24 h) significantly induces apoptosis via caspase-3 and PARP in MV4;11 cells[1]. Western Blot Analysis[1] Cell Line: MV4;11 cells[1].
MT1 (44.2 and 22.1 µmol/kg, ip daily, for 14 days) significantly delayed leukemia progression in mice (Mus musculus) compared to JQ1[1].MT1 exhibits terminal t1/2 of 2.70 h in mice[1]. Animal Model: Leukemia xenograft models[1].
[1]. Minoru Tanaka, et al. Design and characterization of bivalent BET inhibitors. Nat Chem Biol. 2016 Dec;12(12):1089-1096.
Average Rating: 5 (Based on Reviews and 8 reference(s) in Google Scholar.)
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