N-Boc-PEG9-alcohol |
| Catalog No.GC66730 |
N-Boc-PEG9-alcohol es un conector PROTAC basado en PEG/alquilo/éter que se puede utilizar en la síntesis de PROTAC. N-Boc-PEG9-alcohol es un enlazador de ADC escindible que se utiliza en la síntesis de conjugados de anticuerpo-fármaco (ADC).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2112731-44-7
Sample solution is provided at 25 µL, 10mM.
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N-Boc-PEG9-alcohol is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG9-alcohol is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
[1]. Nello Mainolfi, wt al. Irak degraders and uses thereof. US20190192668A1.
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