N-(n-Butyl)deoxygalactonojirimycin (Synonyms: Lucerastat, NBDGJ) |
| Catalog No.GC41235 |
La N-(n-butil)desoxigalactonojirimicina, la forma de galactosa de Miglustat, es un inhibidor de la glucosilceramida sintasa (GCS) disponible por vÍa oral.
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Cas No.: 141206-42-0
Sample solution is provided at 25 µL, 10mM.
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N-(n-Butyl)deoxygalactonojirimycin is an inhibitor of α-D-galactosidase. It has also been shown to prevent glucosylceramide biosynthesis both in vitro and in mouse models of lysosome storage disorders by inhibiting the ceramide-specific glucosyltransferase, UDP-glucose ceramide glucosyltransferase (IC50 = 41.4 µM) without affecting α-glucosidase I and II or β-glucocerebrosidase (IC50s > 1 mM). This compound has been used to sensitize cultured chronic lymphocytic leukemia cells to the chemotherapeutic agents cladribine , chlorambucil , and fludarabine .
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