N-Nitroso-N-methylaniline (Synonyms: N-methyl-N-Nitrosoaniline, NMA, NSC 137) |
Catalog No.GC49859
One-Click Copy Product Info
|
An N-nitrosamine
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 614-00-6
Sample solution is provided at 25 µL, 10mM.
_1-3.$$$39978408@51.jpg');)
_1-9.$$$38538795@65.jpg');)
_1-9.$$$39112701@51.jpg');)
_1-7.$$$37316672@70.jpg');)
_366-372.$$$36198801@70.jpg');)
.$$$38565142@65.jpg');)
_1867-1883.$$$33248023@67.jpg');)
_eads6055.$$$39977546@45.jpg');)
_eadm9805.$$$40080571@45.jpg');)
_eadj3020.$$$39666821@45.jpg');)
_1-20.$$$39757301@28.jpg');)
_1-24.$$$38898113@28.jpg');)
_273-287.$$$36806353@46.jpg');)
_1-16.$$$37156877@44.jpg');)
_1-19.$$$37460805@44.jpg');)
_1291-1307.$$$34518654@46.jpg');)
N-Nitroso-N-methylaniline is an N-nitrosamine.1 It induces the formation of esophageal, pharyngeal, and tongue tumors in rats when administered at a concentration of 200 mg/L in the drinking water or 15 mg/ml via oral gavage.2 N-Nitroso-N-methylaniline is toxic to rats with LD50 values of 336 and 225 mg/kg for male and female rats, respectively. It reduces survival of hamsters but only induces a low incidence of tumors in this species when administered at a dose of 5 mg/week for a total dose of 1.8 mmol.1
1.Lijinsky, W., and Kovatch, R.M.Comparative carcinogenesis by nitrosomethylalkylamines in Syrian hamstersCancer Res.48(23)6648-6652(1988) 2.Goodall, C.M., Lijinsky, W., Tomatis, L., et al.Toxicity and oncogenicity of nitrosomethylaniline and nitrosomethylcyclohexylamineToxicol. Appl. Pharmacol.17(2)426-432(1970)
| Cas No. | 614-00-6 | SDF | |
| Sinónimos | N-methyl-N-Nitrosoaniline, NMA, NSC 137 | ||
| Canonical SMILES | O=NN(C)C1=CC=CC=C1 | ||
| Formula | C7H8N2O | M.Wt | 136.2 |
| Solubility | Chloroform: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 7.3421 mL | 36.7107 mL | 73.4214 mL |
| 5 mM | 1.4684 mL | 7.3421 mL | 14.6843 mL |
| 10 mM | 734.2 μL | 3.6711 mL | 7.3421 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solution in ethanol
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 25 reference(s) in Google Scholar.)