NNMTi |
| Catalog No.GC50601 |
NNMTi es un potente inhibidor de la nicotinamidaN-metiltransferasa (NNMT) (IC50 = 1,2 μM) y se une selectivamente a los residuos del sitio de uniÓn al sustrato de NNMT.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 42464-96-0
Sample solution is provided at 25 µL, 10mM.
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Nicotinamide N-methyltransferase (NNMT) inhibitor (IC50 = 1.2 μM). Promotes myoblast differentiation in C2C12 cells. Activates senescent muscle stem cells (muSCs) and improves regenerative capacity of aged skeletal muscle. Enhances proliferation, fusion and regenerative capacity of muSCs in aged mice.
Neelakantan et al (2019) Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. Biochem. Pharmacol. 163 481 PMID:30753815 |Neelakantan et al (2017) Structure-activity relationship for small molecule inhibitors of nicotinamide N-methyltransferase. J.Med.Chem. 60 5015 PMID:28548833
Average Rating: 5 (Based on Reviews and 31 reference(s) in Google Scholar.)
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