NSC 15520 |
| Catalog No.GC46190 |
An inhibitor of RPA70 dsDNA binding
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 730960-98-2
Sample solution is provided at 25 µL, 10mM.
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NSC 15520 is an inhibitor of replication protein A 70 (RPA70) dsDNA binding.1 It selectively inhibits dsDNA over ssDNA binding to RPA70 when used at concentrations ranging from 25 to 400 μM. NSC 15520 also inhibits the protein-protein interaction between the cell cycle checkpoint control proteins p53 or Rad9 and RPA70.
|1. Glanzer, J.G., Liu, S., and Oakley, G.G. Small molecule inhibitor of the RPA70 N-terminal protein interaction domain discovered using in silico and in vitro methods. Bioorg. Med. Chem. 19(8), 2589-2595 (2011).
Average Rating: 5 (Based on Reviews and 11 reference(s) in Google Scholar.)
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