ONO-7475 (Synonyms: ONO-7475) |
| Catalog No.GC18416 |
ONO-7475 es un inhibidor de Axl/Mer potente, selectivo y oralmente activo con valores IC50 de 0,7 nM y 1,0 nM, respectivamente. ONO-7475 sensibiliza las células de NSCLC mutantes de EGFR que sobreexpresan AXL a los EGFR-TKI, suprime la apariciÓn y el mantenimiento de células tolerantes. ONO-7475 combinado con Osimertinib ofrece una gran promesa para el estudio del cÁncer de pulmÓn de células no pequeÑas (CPCNP) con mutaciÓn de EGFR.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1646839-59-9
Sample solution is provided at 25 µL, 10mM.
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ONO-7475 is a potent and orally active Axl/Mer inhibitor. ONO-7475 targets and binds to both Axl and Mer, and prevents their activity. This blocks Axl- and Mer-mediated signal transduction pathways, and inhibits proliferation and migration of Axl- and Mer-overexpressing tumor cells. Axl and Mer, both members of the TAM (Tyro3, Axl and Mer) family of RTKs, are overexpressed by many tumor cell types. They play key roles in tumor cell proliferation, survival, invasion, angiogenesis and metastasis, and their expression is associated with drug resistance and poor prognosis
Reference:
[1]: Okura N, Nishioka N, Yamada T, Taniguchi H, Tanimura K, Katayama Y, Yoshimura A, Watanabe S, Kikuchi T, Shiotsu S, Kitazaki T, Nishiyama A, Iwasaku M, Kaneko Y, Uchino J, Uehara H, Horinaka M, Sakai T, Tanaka K, Kozaki R, Yano S, Takayama K. ONO-7475, a Novel AXL Inhibitor, Suppresses the Adaptive Resistance to Initial EGFR-TKI Treatment in EGFR-Mutated Non-Small Lung Cancer. Clin Cancer Res. 2020 Jan 17. doi: 10.1158/1078-0432.CCR-19-2321. Epub ahead of print. PMID: 31953310.
[2]: Ruvolo PP, Ma H, Ruvolo VR, Zhang X, Mu H, Schober W, Hernandez I, Gallardo M, Khoury JD, Cortes J, Andreeff M, Post SM. Anexelekto/MER tyrosine kinase inhibitor ONO-7475 arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells by diverse mechanisms. Haematologica. 2017 Dec;102(12):2048-2057. doi: 10.3324/haematol.2017.168856. Epub 2017 Sep 14. PMID: 28912176; PMCID: PMC5709104.
Average Rating: 5 (Based on Reviews and 23 reference(s) in Google Scholar.)
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