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Org41841

Catalog No.GC32423

Org41841 es un agonista parcial tanto de la hormona luteinizante/receptor de gonadotropina coriÓnica (LHCGR) como del receptor de la hormona estimulante de la tiroides (TSHR) con CE50 de 0,2 y 7,7 μM, respectivamente.

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Org41841 Chemical Structure

Cas No.: 301847-37-0

Tamaño Precio Disponibilidad Cantidad
1mg
214,00 $
Disponible
5mg
342,00 $
Disponible
10mg
540,00 $
Disponible

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Sample solution is provided at 25 µL, 10mM.

Description Protocol Chemical Properties Product Documents Related Products

Org41841 is a partial agonist of both luteinizing hormone/chorionic gonadotropin receptor (LHCGR) and thyroid-stimulating hormone receptor (TSHR) with EC50s of 0.2 and 7.7 μM, respectively.

Functional assays demonstrate that Org41841 is a partial agonist of both luteinizing hormone/chorionic gonadotropin receptor (LHCGR) and thyroid-stimulating hormone receptor (TSHR) with EC50s of 0.2 and 7.7 μM, respectively. Treatment of L570F with Org41841 reveals an improved EC50 of 800 nM. M9 responds to Org41841 with an improved EC50 of 2700 nM and a greatly improved efficacy for signaling to 99% of the maximal value observed for thyroid-stimulating hormone (TSH) stimulation of thyroid-stimulating hormone receptor (TSHR)[1].

[1]. Holger Jaschke, et al. A low molecular weight agonist signals by binding to the transmembrane domain of thyroid-stimulating hormone receptor (TSHR) and luteinizing hormone/chorionic gonadotropin receptor(LHCGR). J Biol Chem. 2006 Apr 14;281(15):9841-4.

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Average Rating: 5 ★★★★★ (Based on Reviews and 40 reference(s) in Google Scholar.)

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