Picrocrocin |
| Catalog No.GC60288 |
Picrocrocina, un apocarotenoide que se encuentra en las flores de Cochliobolus sativus. La picrocrocina muestra un efecto anticancerÍgeno. La picrocrocina exhibe efectos inhibidores del crecimiento contra las células de melanoma maligno humano SKMEL-2.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 138-55-6
Sample solution is provided at 25 µL, 10mM.
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Picrocrocin, an apocarotenoid found in the flowers of Cochliobolus sativus. Picrocrocin shows anticancer effect. Picrocrocin exhibits growth inhibitory effects against SKMEL-2 human malignant melanoma cells[1].
Picrocrocin exerted growth inhibitory effects on the SK-MEL-2 melanoma cells. The IC50 of picrocrocin against the SK-MEL-2 cells was 20 μM at 24-h incubation. The antiproliferative activity of picrocrocin was due to apoptosis and cell cycle arrest. In addition, picrocrocin enhanced the ROS levels and decreased the MMP levels of SK-MEL-2 cells. Finally, picrocrocin inhibited the JAK/STAT5 signalling pathway in the SK-MEL-2 melanoma cells[1].
[1]. Yu L, et al. Picrocrocin exhibits growth inhibitory effects against SKMEL- 2 human malignant melanoma cells by targeting JAK/ STAT5 signaling pathway, cell cycle arrest and mitochondrial mediated apoptosis. J BUON. 2018 Jul-Aug;23(4):1163-1168.
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