PLLA-NH2 (M.Wt 40k) (Synonyms: HO-PLLA-NH2) |
Catalog No.GC26195
One-Click Copy Product Info
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PLLA-NH2 es un poliéster biodegradable (ácido poliláctico) que presenta grupos amino en la superficie, lo que lo convierte en un candidato ideal para el desarrollo de biomateriales biocompatibles o para la síntesis de vacunas de antígeno-anticuerpos conjugados
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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PLLA-NH2 es un poliéster biodegradable (ácido poliláctico) que presenta grupos amino en la superficie, lo que lo convierte en un candidato ideal para el desarrollo de biomateriales biocompatibles o para la síntesis de vacunas de antígeno-anticuerpos conjugados[1-2]. PLLA-NH2 se puede combinar directamente con el antígeno de proteína modelo ovalbúmina (OVA) para fabricar nanovacunas. Tras la administración subcutánea de la vacuna a base de PLLA-NH2 (200.0μg) en ratones C57BL/6N (6-7 semanas de edad) durante 21 días, la vacuna a base de PLLA-NH2 facilita el transporte eficiente a los ganglios linfáticos, lo que provoca una respuesta inmune anticancerígena sostenida. La vacuna basada en PLLA-NH2 es fundamental para promover la maduración de las células dendríticas, la presentación de antígenos y la activación de los linfocitos T [2]. PLLA-NH2 se puede utilizar como bloque de construcción para la síntesis de un nuevo copolímero de dibloque biodegradable:poli (L-cysteine) -b-poly (L-lactide) (PLC-b-PLLA) en presencia de polimerización de apertura de anillo (ROP) de N-carboxyanhydride de β-benzyloxycarbonyl-l-cysteine (ZLC-NCA). La nueva película de polímero a base de PLLA-NH2 puede soportar el crecimiento adherente de las células ECV-304, y tanto la adhesión celular como la propagación celular se mejoraron[3-4].
References:
[1] Ouchi T, Minari T, Ohya Y. Synthesis of poly (l‐lactide)‐grafted pullulan through coupling reaction between amino group end‐capped poly (l‐lactide) and carboxymethyl pullulan and its aggregation behavior in water[J]. Journal of Polymer Science Part A: Polymer Chemistry, 2004, 42(21): 5482-5487.
[2] Xu W, Su Y, Ma Y, et al. Immunologically effective poly (D-lactic acid) nanoparticle enhances anticancer immune response[J]. Science China Chemistry, 2023, 66(4): 1150-1160.
[3] Chu B, Li X, Fan S, et al. CD34 antibody-coated biodegradable fiber membrane effectively corrects atrial septal defect (ASD) by promoting Endothelialization[J]. Polymers, 2022, 15(1): 108.
[4] Sun J, Chen X, Lu T, et al. Formation of reversible shell cross-linked micelles from the biodegradable amphiphilic diblock copolymer poly (L-cysteine)-block-poly (L-lactide)[J]. Langmuir, 2008, 24(18): 10099-10106.
| Cas No. | SDF | ||
| Sinónimos | HO-PLLA-NH2 | ||
| Formula | M.Wt | 40k | |
| Solubility | organic solvent | Storage | Store at -20°C,protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 25 μL | 125 μL | 250 μL |
| 5 mM | 5 μL | 25 μL | 50 μL |
| 10 mM | 2.5 μL | 12.5 μL | 25 μL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)