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Prostaglandin D2-d4 (Synonyms: PGD2d4)

Catalog No.GC47988 Copy One-Click Copy Product Info

An internal standard for the quantification of prostaglandin D2

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Prostaglandin D2-d4 Chemical Structure

Cas No.: 211105-29-2

Tamaño Precio Disponibilidad Cantidad
25 μg
143,00 $
Disponible
50 μg
271,00 $
Disponible
100 μg
509,00 $
Disponible

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Sample solution is provided at 25 µL, 10mM.



Description of Prostaglandin D2-d4

Prostaglandin D2-d4 (PGD2-d4) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of PGD2 by GC- or LC-mass spectrometry. PGD2 is the major eicosanoid product of mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. Mastocytosis patients produce excessive amounts of PGD2, which causes vasodilation, flushing, hypotension, and syncopal episodes. PGD2 is also produced in the brain via an alternative pathway involving a soluble, secreted PGD-synthase also known as β-trace.2,3 In the brain, PGD2 produces normal physiological sleep and lowering of body temperature. Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle. PGD2 inhibits human ovarian tumor cell proliferation with an IC50 of 6.8 µM.

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Chemical Properties of Prostaglandin D2-d4

Cas No. 211105-29-2 SDF
Sinónimos PGD2d4
Canonical SMILES O[C@@H](C1)[C@H](C/C=C\C([2H])([2H])C([2H])([2H])CC(O)=O)[C@@H](/C=C/[C@@H](O)CCCCC)C1=O
Formula C20H28D4O5 M.Wt 356.5
Solubility DMF: >100 mg/ml (from PGD2),DMSO: >50 mg/ml (from PGD2),Ethanol: >75 mg/ml (from PGD2),PBS pH 7.2: >5 mg/ml (from PGD2) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Prostaglandin D2-d4

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.805 mL 14.0252 mL 28.0505 mL
5 mM 561 μL 2.805 mL 5.6101 mL
10 mM 280.5 μL 1.4025 mL 2.805 mL
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In vivo Formulation Calculator (Clear solution) of Prostaglandin D2-d4

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 9 reference(s) in Google Scholar.)

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