(R)-(-)-Linoleyl-2'-Hydroxy-1'-Propylamide |
| Catalog No.GC41708 |
N-Acyl ethanolamines (NAEs) have diverse biological actions that are strongly affected by the associated acyl group.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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N-Acyl ethanolamines (NAEs) have diverse biological actions that are strongly affected by the associated acyl group. Linoleoyl ethanolamide (LOEA) has potential signaling roles in aging and neurological functioning. LOEA has a weak affinity for cannabinoid (CB) receptors (Ki = 10, 25 μM for CB1, CB2, respectively) and inhibits voltage-gated K+ channels. LOEA also inhibits fatty acid amide hydrolase (FAAH; Ki = 9 μM) and is hydrolyzed by FAAH. (R)-(-)-Linoleyl-2'-hydroxy-1'-propylamide is a homolog of LOEA which is characterized by the addition of an (R)-β-methyl group at the terminal ethanolamine carbon. A similar modification of arachidonoyl ethanolamide to produce R-2 methanandamide imparts diminished affinity for the CB receptor as well as reduced metabolic stability. The physiological actions of this compound have not been evaluated.
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