Relatlimab (Synonyms: BMS-986016) |
| Catalog No.GC66381 |
Relatlimab (BMS-986016) es un anticuerpo monoclonal humano anti-LAG-3 generado mediante la inmunizaciÓn de ratones transgénicos que portan miniloci de inmunoglobulina humana con proteÍna LAG-3 recombinante. Relatlimab bloquea la interacciÓn LAG-3/MHC II con un valor IC50 de 0,67 nM y la interacciÓn LAG-3/FGL1 con un valor IC50 de 0,019 nM. Relatlimab se puede utilizar en la investigaciÓn del cÁncer.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1673516-98-7
Sample solution is provided at 25 µL, 10mM.
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Relatlimab (BMS-986016) is a human monoclonal antibody anti-LAG-3 antibody generated by immunization of transgenic mice bearing human immunoglobulin miniloci with recombinant LAG-3 protein. Relatlimab blocks LAG-3/MHC II interaction with an IC50 value of 0.67 nM and LAG-3/FGL1 interaction with an IC50 value of 0.019 nM. Relatlimab can be used in research of cancer[1].
Relatlimab (BMS-986016; 0.001-100 nM) recognizes native LAG-3 and binds to primary activated human and cynomolgus CD4+ T cells with EC50 values of 0.11 nM and 29.11 nM, respectively[1].
Relatlimab (0.001-10000 nM; T cells (3A9-hLAG-3)) enhances peptide responsiveness of T-cell hybridoma 3A9-hLAG-3 and reversals LAG-3-mediated inhibition of T-cell hybridoma 3A9-hLAG-3 with an IC50 value of 1.05 nM[1].
Relatlimab (0.001-10000 nM; primary T cells) enhances activation of superantigen-stimulated human PBMC cultures and enhances IL-2 secretion[1].
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