GPCR/G protein

(R)-Octopamine is a Gs-coupled receptor agonist.

Tuaminoheptane sulfate is an alpha- adrenergic receptor agonist.

Toliprolol is a β 1 /β 2 -selective β- adrenergic Receptor antagonist.

α2AR agonist 2 is a selective α2B adrenergic receptor antagonist ( IC 50 = 1.2 µM).

Brefonalol (Brefanolol) hydrochloride is an orally active, non-selective β-adrenergic receptor blocker with vasodilatory properties.

α1A/1D-Adrenoceptor antagonist-1 (Compound 15) is a selective α1A/1D-adrenoceptor dual antagonist with IC 50 values of 20.26 and 164.9 nM.

KMCA-0011 is an orally active ɑ 2C adrenoceptor antagonist ( K i = 56.7 nM).

PF-610355 hydrochloride is a β2 - adrenergic receptor ( β2-AR ) full agonist with selectivity for β1-adrenergic receptors.

RESA peptide is a substrate peptide of β-adrenergic receptor kinase (βARK).

Napamezole hydrochloride is an orally active α-2 adrenergic receptor antagonist and serotonin ( 5-HT Receptor ) reuptake inhibitor, with K i values of 28 nM and 93 nM for rat α-2 and α-1 adrenergic receptors, respectively.

β2AR-IN-15 is a selective β2-adrenergic receptor ( β2AR ) antagonist with a K d of 1.7 μM.

CTR/AMYR modulator-2 is a dual agonist of human amylin receptor 3 ( AMY3R ) and calcitonin receptor ( CTR ).

KBP-089 is a dual Amylin and Calcitonin Receptor agonist.

Gramine-d 2 is the deuterium labeled Gramine [1] . Gramine (Donaxine) is a natural alkaloid isolated from giant reed [2] , acts as an active adiponectin receptor (AdipoR) agonist, with IC 50 s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively [2] . Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist [3] . Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties [2] .

Solaprubart (STAR-0310) is a fully human IgG1 subtype monoclonal antibody targeting OX40 (CD134/TNFRSF4), with a K d of 7.2 nM.

Vedastotug is a human monoclonal antibody targeting TNFRSF4/OX40/CD134, with its corresponding isotype control being Human IgG1 kappa, Isotype Control [1] .

CTR/AMYR modulator-1 is a calcitonin receptor/amylin receptor modulator.

CCKBR agonist-2 (Compound z-44) is a Gi-preferring CCKBR agonist.

Mazapertine is an orally active antipsychotic agent.

PG-901 is a full, selective MC5R agonist ( EC 50 = 0.072 nM for hMC5R).

PIPE-791 is an orally active, blood-brain barrier-permeable selective antagonist of LPAR1.

Betovumeline hydrochloride is the agonist for muscarinic receptor and can be used for researchs of neurological disorders [1] .

4-Piperidyl N-(2-biphenyl)carbamate (compound MA) is a competitive muscarinic acetylcholine receptor ( mAChR ) antagonist.

Direclidine (NBI-1117568, HTL-0016878) citrate is a selective orthosteric agonist targeting the muscarinic acetylcholine M4 receptor, exhibiting very low affinity for M1, M2, M3, and M5 receptors.