GPR84

GPR84 is a G protein-coupled receptor for medium-chain fatty acids. GPR84 is a receptor for free fatty acids and can be potently activated by saturated medium-chain free fatty acids (MCFAs) like decanoic acid, undecanoic acid and lauric acid. GPR84, a receptor for medium-length free fatty acids is upregulated on protein level in LPS activated tolerant CD14⁺ monocytes and THP-1 cells.

GPR84 is activated by MCFAs with the hydroxyl group at the 2- or 3-position more effectively than nonhydroxylated MCFAs. GPR84 is now considered to be a member of FFA-sensing GPCRs. MCFAs with carbon chain lengths of 9–14 activate GPR84, coupling primarily to a pertussis toxin (PTX)-sensitive G_i/o pathway. GPR84 should be a proinflammatory receptor and may be a novel, attractive target for treating chronic low grade inflammation associated-diseases.

Products for GPR84

Cat.No. Nombre del producto Información
GC11350 6-OAU 6-OAU (GTPL5846) (6-n-octilaminouracilo) es un agonista de GPR84 (receptor 84 acoplado a proteÍna G), con un valor EC50 de 105 nM.
GC64229 GPR84 antagonist 1 El antagonista 1 de GPR84 es un antagonista competitivo altamente selectivo y de alta afinidad del GPR84 humano.
GC31712 GPR84 antagonist 8 El antagonista 8 de GPR84 es un antagonista selectivo de GPR84.
GC31698 PBI-4050 sodium salt (Setogepram (sodium salt)) Fezagepras (Setogepram) sÓdico actÚa como un agonista activo por vÍa oral para GPR40 y como antagonista o agonista inverso para GPR84.