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RGS Protein

RGS (Regulators of G protein signaling) are protein structural domains that activate GTPases for heterotrimeric G-protein alpha-subunits. RGS proteins are multi-functional, GTPase-accelerating proteins that promote GTP hydrolysis by the alpha subunit of heterotrimeric G proteins, thereby inactivating the G protein and rapidly switching off G protein-coupled receptor signaling pathways. Upon activation by GPCRs, heterotrimeric G proteins exchange GDP for GTP, are released from the receptor, and dissociate into free, active GTP-bound alpha subunit and beta-gamma dimer, both of which activate downstream effectors. The response is terminated upon GTP hydrolysis by the alpha subunit, which can then bind the beta-gamma dimer and the receptor. RGS proteins markedly reduce the lifespan of GTP-bound alpha subunits by stabilising the G protein transition state. All RGS proteins contain an RGS-box (or RGS domain), which is required for activity. Some small RGS proteins such as RGS1 and RGS4 are little more than an RGS domain, while others also contain additional domains that confer further functionality.

Targets for  RGS Protein

Products for  RGS Protein

  1. Cat.No. Nombre del producto Información
  2. GC30875 CCG 203769 CCG 203769 es un inhibidor selectivo de la seÑalizaciÓn de proteÍna G (RGS4), que bloquea la interacciÓn proteÍna-proteÍna RGS4-Gαo in vitro con una IC50 de 17 nM. CCG 203769  Chemical Structure
  3. GC16137 CCG 2046 CCG 2046 es un inhibidor de RGS4 con una IC50 de 4,3 μM frente a RGS4-Gαo seÑal de interacciÓn. CCG 2046  Chemical Structure
  4. GC16846 CCG 50014 CCG 50014 es el más potente contra el regulador de la proteína de señalización de proteína G tipo 4 (RGS4) (IC50 \u003d 30 nM) y es\u003e 20 veces más selectivo para RGS4 que para otras proteínas RGS. CCG 50014  Chemical Structure
  5. GC10658 CCG-63802 CCG-63802  Chemical Structure
  6. GC14412 CCG-63808 CCG-63808  Chemical Structure

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