MAPK Signaling

(S)-p38 MAPK inhibitor III is a methylsulfanylimidazole that inhibits p38 MAP kinase (IC50 = 0.90 μM in vitro).

7-oxo Staurosporine is an antibiotic originally isolated from S.

8-bromo-Cyclic AMP is a brominated derivative of cAMP that remains long-acting due to its resistance to degradation by cAMP phosphodiesterase.

Exchange proteins activated by cAMP (Epacs) are guanine nucleotide exchange factors (GEFs) for the small GTPases Rap1 and Rap2.

AR420626 is an oral active and selective agonist of free fatty acid receptor 3 (FFAR3) with an EC 50 value of 2.2µM.

BPIQ-II is a linear imidazoloquinazoline that potently inhibits the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 8 pM).

C2 Phytoceramide is a bioactive semisynthetic sphingolipid that inhibits formyl peptide-induced oxidant release (IC50 = 0.38 μM) in suspended polymorphonuclear cells.

The extracellular signal-regulated kinase (ERK) signal transduction pathway regulates a diverse array of cellular processes.

CAY10717 is a multi-targeted kinase inhibitor that exhibits greater than 40% inhibition of 34 of 104 kinases in an enzymatic assay at a concentration of 100 nM.

Compound 43 TAO kinase inhibitor is an ATP-competitive inhibitor of the thousand-and-one amino acid kinases TAOK1 and TAOK2 (IC50s = 11 and 15 nM, respectively).

The Survival of Motor Neurons (SMN) protein participates in RNA splicing.

Guanosine 3',5'-cyclic monophosphate (cyclic GMP or cGMP) is a second messenger that is biosynthesized from GTP by guanylate cyclases.

La enniatina A1 aislada de las micotoxinas de Fusarium es un hexadepsipéptido cÍclico que consta de Ácidos D-α-hidroxiisovalérico alternados y N-metil-L-aminoÁcidos. Enniatin A1 posee propiedades anticancerÍgenas mediante la inducciÓn de apoptosis y la interrupciÓn de la vÍa de seÑalizaciÓn de ERK. Enniatin A1 inhibe ACAT con un IC50 de 49 μM en microsomas de hÍgado de rata.

La enniatina B1 es una micotoxina de Fusarium.

ERK inhibitor is a cell-permeable inhibitor that binds ERK2 near its docking domain (KD = 5 μM).

Ganglioside GQ1b is a tetrasialoganglioside that contains two sialic acid residues linked to an inner galactose unit.

Guanylyl Imidodiphosphate (lithium salt), un análogo GTP estable, es un activator potencial de adenilato ciclasal.

Fasudil (HA-1077; AT877) dihidrocloruro es un inhibidor rhoa/roca inespecÍfico y también tiene un efecto inhibitorio en las proteÍnas quinasas, con un KI de 0.33 ⋼ m para el rock111&&&&&&77TRESTO. offlineefficient_models_2022q2.md;M, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively.en_es_2021q4.mdHA-1077 (hydrochloride) is also a potent Ca2+ channel antagonist and vasodilator.en_es_2021q4.md

La hipotemicina, un policétido fÚngico, es un inhibidor multicinasa con Kis de 10/70 nM, 17/38 nM, 90 nM, 900 nM/1,5 μM y 8,4/2,4 μM para VEGFR2/VEGFR1, MEK1/MEK2, FLT-3, PDGFRβ/PDGFRα y ERK1/ERK2, respectivamente.

L-858,051 is a water-soluble analog of forskolin, a cell-permeant activator of adenylate cyclase.

El L-sulforafeno, aislado de semillas de rÁbano, presenta una DE50 frente a plÁntulas de hoja aterciopelada de aproximadamente 2 x 10-4 M. El L-sulforafeno promueve la apoptosis de las células cancerosas e inhibe la migraciÓn mediante la inhibiciÓn de EGFR, p-ERK1/2, NF‐κB y otros seÑales

LY2584702 (tosylate) es un inhibidor competitivo potente y altamente slectivo del trifosfato de adenosina (ATP) contra la quinasa p70 S6, un componente aguas abajo de la vía de señalización de la phosphatidylinositol-3-quinasa con un valor IC 50 de 0.004μM.

Methylcarbamyl PAF C-8 is the C-8 analog of Methylcarbamyl PAF C-16.

El inhibidor de MK2 III (compuesto 16) es un inhibidor de MAPKAP-K2 (MK-2) activo por vÍa oral, selectivo y competitivo con ATP con una IC50 de 0,85 nM.