Enniatin A1 |
| Catalog No.GC43610 |
La enniatina A1 aislada de las micotoxinas de Fusarium es un hexadepsipéptido cÍclico que consta de Ácidos D-α-hidroxiisovalérico alternados y N-metil-L-aminoÁcidos. Enniatin A1 posee propiedades anticancerÍgenas mediante la inducciÓn de apoptosis y la interrupciÓn de la vÍa de seÑalizaciÓn de ERK. Enniatin A1 inhibe ACAT con un IC50 de 49 μM en microsomas de hÍgado de rata.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 4530-21-6
Sample solution is provided at 25 µL, 10mM.
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Enniatins are cyclohexadepsipeptides commonly isolated from fungi that are known to have antibiotic properties and to induce apoptosis in several cancer lines. Many function as ionophores, forming pores in cellular membranes to allow selective ion transport. Enniatin A1 is one of four major analogs in the enniatin complex . Its ionophoric activity has been described. Additionally, enniatin A1 has been found to induce apoptosis in cancer cells (EC50 = 5 µM in H4IIE rat hepatoma cells), decreasing the activation of the cell proliferation kinase, ERK (p44/p42) and inhibiting TNF-α-induced NF-κB activation.
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