DGAT
Acyl-CoA: diacylglycerol acyltransferase (DGAT) is an enzyme involved in the biosynthesis of triacylglycerol (TG) that catalyze the final step in the sn-glycerol-3-phosphate (G3P) pathway esterifying diacylglycerol (DG) to produce TG. With the development of techniques in genomics, bioinformatics, transgenics and protein purification, genes encoding two major types of DGAT have been identified, DGAT1 (10.62 kb with 17 exons) and DGAT2 (42.03 kb with 8 exons), which encode two DGAT enzymes with approximately 35% difference in length. Although the two DGAT enzymes have no sequence homology, they exhibit similar activities in the biosynthesis of TG. However, DGAT2 enzyme appears to be a more potent DGAT with a higher affinity towards its substrates than DGAT1 enzyme.
Products for DGAT
- Cat.No. Nombre del producto Información
- GC11675 Amidepsine A La amidapsina A es un metabolito fÚngico aislado del caldo de cultivo de Humicola sp.
- GC17013 Amidepsine D La amidapsina D es un metabolito fÚngico aislado del caldo de cultivo de Humicola sp.
- GC16257 AZD 3988 AZD 3988 es un inhibidor de la diacilglicerol acil transferasa-1 (DGAT-1) activo por vía oral.
- GC11475 AZD7687
- GC16133 DGAT-1 inhibitor A DGAT-1 inhibitor
- GC50285 JNJ DGAT2-A JNJ DGAT2-A es un inhibidor selectivo de la diacilglicerol aciltransferasa 2 (DGAT2) con un valor IC50 de 0,14 μM en membranas de células de insectos Sf9 que expresan DGAT2 humana.
- GC11036 LCQ-908